![]() One commonly applied definition has described an inability to achieve pregnancy after the transfer of at least ten embryos, but at the time, say the authors of the F&S study, it was likely that many such cases had undetected chromosomally abnormal embryos to explain the diagnosis. ![]() The ESHRE report also noted a prevalence of recurrent implantation failure of around 10%, with two-thirds of respondents implicating ‘lifestyle factors’. This was the conclusion also reached by a recent survey report from ESHRE’s SIG Implantation & Early Pregnancy, which similarly found ‘no consensus’ on a precise meaning.(2) Definitions were of high variability, and ‘generally based on the number of unsuccessful IVF cycles, the number of embryos transferred or a combination of both factors’. The authors note that there is presently no universally accepted definition of recurrent implantation failure. Implantation rates over the three transfer cycles were 69.9% in the first, 59.8% in the second and 60.3% in the third, indicating, said the authors, ‘that failed implantation after a FE-SET does not select out women with overt receptivity disorders’. The study, which reviewed results from all patients having up to three consecutive frozen PGT-A SETs between 20 at the RMA clinic in New Jersey, found a cumulative implantation rate of 95.2% (and a live birth rate only slightly lower) in the study cohort, suggesting to them that ‘a pathology inherent to the endometrium is rare’. The most I ever had from a single cycle was 2, and when using our own gametes (when we could barely make blasts) we believe we both had issues over time that couldn’t be assisted.A large retrospective study, billed as a ‘seminal contribution’ to January’s Fertility & Sterility, has concluded that recurrent implantation failure is a ‘rare’ condition, with just 5% of IVF patients with euploid embryos unable to achieve pregnancy following three consecutive SETs.(1) The results, write the authors, raise the question of whether there is a truly ‘recalcitrant’ group of IVF patients unable to sustain implantation, or if there is indeed an enigmatic endometrial factor requiring specific evaluation and treatment. With so many PGS normals, there is a lot going for you. Wishing you strength in the days to come and lots of support, and hoping next time there is a much better outcome. I have no idea what to make of our journey but ultimately after 6 years since our OE success and trying so many different cycle types, PGS never helped but using both donor gametes finally paid off. Interesting using donor egg and double donor PGS tested embryos resulted in BFNs and those were my most hopeful cycles with the best looking blasts. So in my case my current pregnancy and child are untested embryos. MENTS: My history:ġ child from OE IVF (day 3 transfer, untested)Ħ failed fresh cycles and related transfers, incl 1 chemical and 1 mcġ fresh donor cycle with 1 PGS normal embryo - BFNġ fresh donor cycle (new donor) and 2 untested blasts transferred, mc 5 weeksġ double donor embryo transfer of 2 untested embryos - BFNġ double donor embryo transfer of 1 PGS tested embryo (top graded and almost fully hatched) - BFNġ double donor embryo transfer of 2 untested embryos - currently 19 weeks pregnant. We really had to try many things and persistence in our case paid off.
0 Comments
Leave a Reply. |